Instructions:

Jose Luis Cabrera Alarcon

2019-03-16

This is a shiny app for FCS/FCSM scores calculation, to aid in variant prioritization in nuclear and mitochondrial single nucleotide variants.

1. Click on “FCS” or “FCSM” to select the score to calculate.

2. Click on “browser" to upload variants data.

Uploaded data must be in tab separated values with ".tsv" or ".txt" extesion. This file must contain the following variables under these exact headers:

Locus_variability

Phastcons

phyloP

GranthamScore

MODIFIER

MODERATE

HIGH

LOW

OPTIONAL: You can change the purpose cutoff value to clasify variants in benign or pathogenic:

OPTIONAL: Hit “Download data” to save the results table to a csv file: